S1PC https://validator.w3.org/feed/docs/rss2.html S1PC Website Release Announcement S1PC ブランドサイトリリースのお知らせ Jun-ichiro S et al. Garlic-derived metabolite activates LKB1, promotes adipose eNAMPT secretion, and improves age-related muscle function via hypothalamic signaling. Cell Metab. Online ahead of print. New Findings in Anti-Aging Research on S1PC Published in Cell Metabolism (May 8 (JST)) S1PCの抗老化研究で新知見 Cell Metabolism掲載（5/8(JST)）のお知らせ 【公式YouTubeチャンネル開設のお知らせ】WAKUNAGA Channelを公開 Official YouTube Channel “WAKUNAGA Channel” Now Live Nakamoto M, Kunimura K, Ohtani M. Pharmacokinetics of sulfur-containing compounds in aged garlic extract: S-Allylcysteine, S-1-propenylcysteine, S-methylcysteine, S-allylmercaptocysteine, and others (Review). Exp Ther Med. 2025 Mar 26;29(5):102. Nakamoto M, Kunimura K, Ohtani M. Pharmacokinetics of sulfur-containing compounds in aged garlic extract: S-Allylcysteine, S-1-propenylcysteine, S-methylcysteine, S-allylmercaptocysteine, and others (Review). Exp Ther Med. 2025 Mar 26;29(5):102. Kunimura K, Nakamoto M, Ushijima M. S-1-Propenylcysteine enhances endurance capacity of mice by stimulating fatty acid metabolism via muscle isoform of carnitine. J Nutr. 2024 Sep;154(9):2707-2716. Kunimura K, Nakamoto M, Ushijima M. S-1-Propenylcysteine enhances endurance capacity of mice by stimulating fatty acid metabolism via muscle isoform of carnitine. J Nutr. 2024 Sep;154(9):2707-2716. Nango H, Ohtani M. S-1-propenyl-L-cysteine suppresses lipopolysaccharide-induced expression of matrix metalloproteinase-1 through inhibition of tumor necrosis factor-α converting enzyme-epidermal growth factor receptor axis in human gingival fibroblasts. PLoS One. 2023 Apr 21;18(4):e0284713. Nango H, Ohtani M. S-1-propenyl-L-cysteine suppresses lipopolysaccharide-induced expression of matrix metalloproteinase-1 through inhibition of tumor necrosis factor-α converting enzyme-epidermal growth factor receptor axis in human gingival fibroblasts. PLoS One. 2023 Apr 21;18(4):e0284713. Miki S, Suzuki J, Takashima M et al. S-1-Propenylcysteine promotes IL-10-induced M2c macrophage polarization through prolonged activation of IL-10R/STAT3 signaling. Sci Rep. 2021 Nov 17;11(1):22469. Miki S, Suzuki J, Takashima M et al. S-1-Propenylcysteine promotes IL-10-induced M2c macrophage polarization through prolonged activation of IL-10R/STAT3 signaling. Sci Rep. 2021 Nov 17;11(1):22469. Kunimura K, Miki S, Takashima M, Suzuki J. S-1-propenylcysteine improves TNF-α-induced vascular endothelial barrier dysfunction by suppressing the GEF-H1/RhoA/Rac pathway. Cell Commun Signal. 2021 Feb 15;19(1):17. Kunimura K, Miki S, Takashima M, Suzuki J. S-1-propenylcysteine improves TNF-α-induced vascular endothelial barrier dysfunction by suppressing the GEF-H1/RhoA/Rac pathway. Cell Commun Signal. 2021 Feb 15;19(1):17. Ushijima M, Kunimura K, Suzuki J. S-1-Propenylcysteine, a sulfur compound in aged garlic extract, alleviates cold-induced reduction in peripheral blood flow in rat via activation of the AMPK/eNOS/NO pathway. Exp Ther Med. 2020 Sep;20(3):2815-2821. Ushijima M, Kunimura K, Suzuki J. S-1-Propenylcysteine, a sulfur compound in aged garlic extract, alleviates cold-induced reduction in peripheral blood flow in rat via activation of the AMPK/eNOS/NO pathway. Exp Ther Med. 2020 Sep;20(3):2815-2821. Ohtani M, Nishimura T. Sulfur-containing amino acids in aged garlic extract inhibit inflammation in human gingival epithelial cells by suppressing the intercellular adhesion molecule-1 expression and IL-6 secretion. Biomed Rep. 2020 Mar;12(3):99-108. Ohtani M, Nishimura T. Sulfur-containing amino acids in aged garlic extract inhibit inflammation in human gingival epithelial cells by suppressing the intercellular adhesion molecule-1 expression and IL-6 secretion. Biomed Rep. 2020 Mar;12(3):99-108. Suzuki J, Miki S, Ushijima M, Kodera Y. Regulation of immune response by S-1-propenylcysteine throught autophagy-mediated protein degradation. Exp Ther Med. 2020 Feb;19(2):1570-1573. Suzuki J, Miki S, Ushijima M, Kodera Y. Regulation of immune response by S-1-propenylcysteine throught autophagy-mediated protein degradation. Exp Ther Med. 2020 Feb;19(2):1570-1573. Matsutomo T, Ushijima M, Kunimura K, Ohtani M. Metabolomic study reveals the acute hypotensive effect of S-1-propenylcysteine accompanied by alteration of the plasma histidine level in spontaneously hypertensive rats. J Pharm Biomed Anal. 2019 May 10;168:148-154. Matsutomo T, Ushijima M, Kunimura K, Ohtani M. Metabolomic study reveals the acute hypotensive effect of S-1-propenylcysteine accompanied by alteration of the plasma histidine level in spontaneously hypertensive rats. J Pharm Biomed Anal. 2019 May 10;168:148-154. Tsuneyoshi T, Kunimura K, Morihara N. S-1-Propenylcysteine augments BACH1 degradation and heme oxygenase 1 expression in a nitric oxide-dependent manner in endothelial cells. Nitric Oxide. 2019 Mar 1;84:22-29. Tsuneyoshi T, Kunimura K, Morihara N. S-1-Propenylcysteine augments BACH1 degradation and heme oxygenase 1 expression in a nitric oxide-dependent manner in endothelial cells. Nitric Oxide. 2019 Mar 1;84:22-29. Ushijima M, Takashima M, Kunimura K, Kodera Y, Morihara N, Tamura K. Effects of S-1-propenylcysteine, a sulfur compound in aged garlic extract, on blood pressure and peripheral circulation in spontaneously hypertensive rats. J Pharm Pharmacol. 2018 Apr;70(4):559-565. Ushijima M, Takashima M, Kunimura K, Kodera Y, Morihara N, Tamura K. Effects of S-1-propenylcysteine, a sulfur compound in aged garlic extract, on blood pressure and peripheral circulation in spontaneously hypertensive rats. J Pharm Pharmacol. 2018 Apr;70(4):559-565. Suzuki J, Kodera Y, Miki S, Ushijima M, Takashima M, Matsutomo T, Morihara N. Anti-inflammatory action of cysteine derivative S-1-propenylcysteine by inducing MyD88 degradation. Sci Rep. 2018 Sep 20;8(1):14148. Suzuki J, Kodera Y, Miki S, Ushijima M, Takashima M, Matsutomo T, Morihara N. Anti-inflammatory action of cysteine derivative S-1-propenylcysteine by inducing MyD88 degradation. Sci Rep. 2018 Sep 20;8(1):14148. Matsutomo T, Ushijima M, Kodera Y, Nakamoto M, Takashima M, Morihara N, Tamura K. Metabolomic study on the antihypertensive effect of S-1-propenylcysteine in spontaneously hypertensive rats using liquid chromatography coupled with quadrupole-Orbitrap mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Mar 1;1046:147-155. Matsutomo T, Ushijima M, Kodera Y, Nakamoto M, Takashima M, Morihara N, Tamura K. Metabolomic study on the antihypertensive effect of S-1-propenylcysteine in spontaneously hypertensive rats using liquid chromatography coupled with quadrupole-Orbitrap mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Mar 1;1046:147-155. Kodera Y, Ushijima M, Amano H, Suzuki J, Matsutomo T. Chemical and Biological Properties of S-1-Propenyl-l-Cysteine in Aged Garlic Extract. Molecules. 2017 Mar 31;22(4):570. Kodera Y, Ushijima M, Amano H, Suzuki J, Matsutomo T. Chemical and Biological Properties of S-1-Propenyl-l-Cysteine in Aged Garlic Extract. Molecules. 2017 Mar 31;22(4):570. Amano H, Kazamori D, Ioth K. Evaluation of the Effects of S-Allyl-L-cysteine, S-Methyl-L-cysteine, trans-S-1-Propenyl-L-cysteine, and Their N-Acetylated and S-Oxidized Metabolites on Human CYP Activities. Biol Pharm Bull. 2016;39(10):1701-1707. Amano H, Kazamori D, Ioth K. Evaluation of the Effects of S-Allyl-L-cysteine, S-Methyl-L-cysteine, trans-S-1-Propenyl-L-cysteine, and Their N-Acetylated and S-Oxidized Metabolites on Human CYP Activities. Biol Pharm Bull. 2016;39(10):1701-1707. Suzuki J, Yamaguchi T, Matsutomo T, Amano H, Morihara N, Kodera Y. S-1-Propenylcysteine promotes the differentiation of B cells into IgA-producing cells by the induction of Erk1/2-dependent Xbp1 expression in Peyer’s patches. Nutrition. 2016 Jul-Aug;32(7-8):884-889. Suzuki J, Yamaguchi T, Matsutomo T, Amano H, Morihara N, Kodera Y. S-1-Propenylcysteine promotes the differentiation of B cells into IgA-producing cells by the induction of Erk1/2-dependent Xbp1 expression in Peyer’s patches. Nutrition. 2016 Jul-Aug;32(7-8):884-889. Amano H, Kazamori D, Ioth K. Pharmacokinetics and N-acetylation metabolism of S-methyl-l-cysteine and trans-S-1-propenyl-l-cysteine in rats and dogs. Xenobiotica. 2016 Nov;46(11):1017-1025. Kodera Y, Matsutomo T, Itoh K. The Evidence for the Production Mechanism of cis-S-1-Propenylcysteine in Aged Garlic Extract Based on a Model Reaction Approach Using Its Isomers and Deuterated Solvents. Planta Med Lett. 2015;2(01):e69-e72. Jun-ichiro S et al. Garlic-derived metabolite activates LKB1, promotes adipose eNAMPT secretion, and improves age-related muscle function via hypothalamic signaling. Cell Metab. Online ahead of print. Amano H, Kazamori D, Ioth K. Pharmacokinetics and N-acetylation metabolism of S-methyl-l-cysteine and trans-S-1-propenyl-l-cysteine in rats and dogs. Xenobiotica. 2016 Nov;46(11):1017-1025. Kodera Y, Matsutomo T, Itoh K. The Evidence for the Production Mechanism of cis-S-1-Propenylcysteine in Aged Garlic Extract Based on a Model Reaction Approach Using Its Isomers and Deuterated Solvents. Planta Med Lett. 2015;2(01):e69-e72. Your inquiry has been submitted. お問い合わせを送信しました TOP（日本語） TOP（英語）