Publications
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S1PC
2026.05
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Jun-ichiro S et al. Garlic-derived metabolite activates LKB1, promotes adipose eNAMPT secretion, and improves age-related muscle function via hypothalamic signaling. Cell Metab. Online ahead of print.
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S1PC
2025.03
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Nakamoto M, Kunimura K, Ohtani M. Pharmacokinetics of sulfur-containing compounds in aged garlic extract: S-Allylcysteine, S-1-propenylcysteine, S-methylcysteine, S-allylmercaptocysteine, and others (Review). Exp Ther Med. 2025 Mar 26;29(5):102.
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S1PC
2024.09
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Kunimura K, Nakamoto M, Ushijima M. S-1-Propenylcysteine enhances endurance capacity of mice by stimulating fatty acid metabolism via muscle isoform of carnitine. J Nutr. 2024 Sep;154(9):2707-2716.
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S1PC
2023.04
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Nango H, Ohtani M. S-1-propenyl-L-cysteine suppresses lipopolysaccharide-induced expression of matrix metalloproteinase-1 through inhibition of tumor necrosis factor-α converting enzyme-epidermal growth factor receptor axis in human gingival fibroblasts. PLoS One. 2023 Apr 21;18(4):e0284713.
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S1PC
2021.11
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Miki S, Suzuki J, Takashima M et al. S-1-Propenylcysteine promotes IL-10-induced M2c macrophage polarization through prolonged activation of IL-10R/STAT3 signaling. Sci Rep. 2021 Nov 17;11(1):22469.
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S1PC
2021.06
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Kunimura K, Miki S, Takashima M, Suzuki J. S-1-propenylcysteine improves TNF-α-induced vascular endothelial barrier dysfunction by suppressing the GEF-H1/RhoA/Rac pathway. Cell Commun Signal. 2021 Feb 15;19(1):17.
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S1PC
2020.09
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Ushijima M, Kunimura K, Suzuki J. S-1-Propenylcysteine, a sulfur compound in aged garlic extract, alleviates cold-induced reduction in peripheral blood flow in rat via activation of the AMPK/eNOS/NO pathway. Exp Ther Med. 2020 Sep;20(3):2815-2821.
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S1PC
2020.06
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Suzuki J, Miki S, Ushijima M, Kodera Y. Regulation of immune response by S-1-propenylcysteine throught autophagy-mediated protein degradation. Exp Ther Med. 2020 Feb;19(2):1570-1573.
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S1PC
2020.03
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Ohtani M, Nishimura T. Sulfur-containing amino acids in aged garlic extract inhibit inflammation in human gingival epithelial cells by suppressing the intercellular adhesion molecule-1 expression and IL-6 secretion. Biomed Rep. 2020 Mar;12(3):99-108.
